Chimerism and Tolerance in Solid Organ Transplantation
نویسندگان
چکیده
J Clin Cell Immunol ISSN:2155-9899 JCCI, an open access journal Transplantation Immunology *Corresponding authors: Suzanne T. Ildstad, M.D., Director, Institute for Cellular Therapeutics, Jewish Hospital, Distinguished Professor of Transplantation, Distinguished University Scholar, Professor of Surgery, University of Louisville, 570 South Preston Street, Suite 404, Louisville, Kentucky 40202-1760, USA, Tel: 502852-2080; Fax: 502-852-2079; E-mail: [email protected]
منابع مشابه
Xenobiotics, chimerism and the induction of tolerance following organ transplantation.
The successful results seen after organ transplantation are largely attributable to the potency and specificity of modern immunosuppressive agents. Although drug-free unresponsiveness to graft alloantigens has not been routinely achieved in clinical practice, recent appreciation of the importance of cell chimerism, which develops after the migration from donor to host of leukocytes contained in...
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Since the start of the clinical vascularized composite allotransplantation (VCA) era over a decade ago this field has witnessed significant developments in both basic and translational research. Transplant tolerance, defined as rejection-free acceptance of transplanted organs or tissues without long-term immunosuppression, holds the potential to revolutionize the field of VCA by removing the ne...
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